UK Biobank (UKB) is widely employed to investigate mental health disorders and related exposures; however, its applicability and relevance in a clinical setting and the assumptions required have not been sufficiently and systematically investigated. …
Background; Donepezil, galantamine, rivastigmine and memantine are potentially effective interventions for cognitive impairment in dementia, but the use of these drugs has not been personalised to individual patients yet. We examined whether …
The contribution of social and behavioural factors in the development of mental health conditions and treatment effectiveness is widely supported, yet there are weak population level data sources on social and behavioural determinants of mental …
Electronic health record systems are ubiquitous and the majority of patients’ data are now being collected electronically in the form of free text. Deep learning has significantly advanced the field of natural language processing and the …
Neural networks (NNs) have become the state of the art in many machine learning applications, such as image, sound (LeCun et al., 2015) and natural language processing (Young et al., 2017; Linggard et al., 2012). However, the success of NNs remains …
Background: Utilisation of routinely collected electronic health records from secondary care offers unprecedented possibilities for medical science research but can also present difficulties. One key issue is that medical information is presented as …
Background: The efficacy of acetylcholinesterase inhibitors and memantine in the symptomatic treatment of Alzheimer's disease is well-established. Randomised trials have shown them to be associated with a reduction in the rate of cognitive decline. …